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5/24/2018

New publication: Conserved degradation of orthologous RLCKs regulates immune homeostasis

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Arabidopsis (Arabidopsis thaliana) AtBIK1 and rice (Oryza sativa) OsRLCK176 are orthologous receptor-like cytoplasmic kinases involved in plant immune signaling. In this Trends in Plant Science Spotlight article, I review several recent studies suggesting that proteasomal turnover of these kinases is regulated by orthologous group IV Ca2+-dependent protein kinases AtCPK28 and OsCPK4, revealing conserved interplay between phosphorylation and ubiquitination in immune homeostasis.  

Read the original articles: 
  • Furlan et al., 2017. Changes in PUB22 ubiquitination modes triggered by MPK3 dampen the immune response. Plant Cell. 
  • Monaghan et al., 2014. The calcium dependent protein kinase CPK28 buffers plant immunity and regulates BIK1 turnover. Cell Host Microbe.
  • Wang et al., 2017. The kinase OsCPK4 regulates a buffering mechanism that fine-tunes innate immunity. Plant Physiology.
  • Wang et al., 2018. A regulatory module controlling homeostasis of a plant immune kinase. Molecular Cell.

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