We are very happy to share our most recent work on BIK1 proteasomal regulation, published this week in Molecular Cell.
This paper is the product of a fruitful collaboration between our lab and that of Jian-Min Zhou at NIBS in Beijing. Congratulations to all authors of this study, but particularly Jinlong Wang (PhD student in the Zhou lab) and Lauren Grubb (MSc student in my lab). Lauren is my very first graduate student and I am very proud of the research she contributed to this study.
Highlights of what we found:
The E3 ligases PUB25 and PUB26 target non-activated immune kinase BIK1 for degradation
PUB25/26 negatively regulate immune responses and disease resistance
CPK28 phosphorylates PUB25/26 to enhance their E3 activity and BIK1 degradation
Heterotrimeric G proteins directly inhibit PUB25/26 E3 activity to stabilize BIK1
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