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New publication: Conserved degradation of orthologous RLCKs regulates immune homeostasis

5/24/2018

 
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Arabidopsis (Arabidopsis thaliana) AtBIK1 and rice (Oryza sativa) OsRLCK176 are orthologous receptor-like cytoplasmic kinases involved in plant immune signaling. In this Trends in Plant Science Spotlight article, I review several recent studies suggesting that proteasomal turnover of these kinases is regulated by orthologous group IV Ca2+-dependent protein kinases AtCPK28 and OsCPK4, revealing conserved interplay between phosphorylation and ubiquitination in immune homeostasis.  

Read the original articles: 
  • Furlan et al., 2017. Changes in PUB22 ubiquitination modes triggered by MPK3 dampen the immune response. Plant Cell. 
  • Monaghan et al., 2014. The calcium dependent protein kinase CPK28 buffers plant immunity and regulates BIK1 turnover. Cell Host Microbe.
  • Wang et al., 2017. The kinase OsCPK4 regulates a buffering mechanism that fine-tunes innate immunity. Plant Physiology.
  • Wang et al., 2018. A regulatory module controlling homeostasis of a plant immune kinase. Molecular Cell.

Welcome, Olivia!

5/5/2018

 
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​Olivia Siemens joined the lab today as a summer student from Western University where she is working towards her Honours Specialization in Genetics in the Department of Biology. We are delighted to have her help with all sorts of daily lab-related tasks. Welcome! 

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